2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE Basic information
- Product Name:
- 2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
- Synonyms:
-
- ML 10302
- 2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
- Monohydrochloride (9CI)
- 2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
- ML 10302 hydrochlorid
- 2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
- CAS:
- 186826-17-5
- MF:
- C15H22Cl2N2O3
- MW:
- 349.25
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- Mol File
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2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: ~44 mg/mL
- form
- solid
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE Usage And Synthesis
Uses
Potent, selective 5-HT4 serotonin receptor agonist. New ester of 4-Amino-5-chloro-2-methoxybenzoic acid as potent agonist and antagonist for 5-HT4 receptors.
in vivo
ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice[3].
| Animal Model: | 8-weeks old adult male C57BL/6j wild-type mice (23-27?g)[3] |
| Dosage: | 5 mg/kg, 10 mg/kg, 20?mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Significantly increased sAPPα level in the cortex. |
IC 50
5-HT4 Receptor: 4 nM (EC50); 5-HT4 Receptor: 1.07 nM (Ki); 5-HT3 Receptor: 782 nM (Ki)
2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATESupplier
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