(1R,2R)-trans-N-Boc-2-Aminocyclohexanol Chemical Properties

Melting point:

110 °C

Boiling point:

337.7±31.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

12.11±0.40(Predicted)

Appearance

White to off-white Solid

optical activity

[α]/D +4.9±0.5°, c = 1 in chloroform

BRN 

6921870

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50

Safety Statements 

61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

HS Code 

2924297099

(1R,2R)-trans-N-Boc-2-Aminocyclohexanol Usage And Synthesis

Synthesis

Step B: Preparation of tert-butyl (1R,2R)-(2-hydroxycyclohexyl)carbamate To a mixed solution of tert-butyl (1R,2R)-(2-benzyloxycyclohexyl)carbamate (7 g, 23 mmol) in ethyl acetate and methanol (80 mL, 9:1) was added 10% Pd-C catalyst (1.13 g). The hydrogenation reaction was carried out at 35 psi hydrogen pressure for 4 hours. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated to give the target product (Cas:155975-19-2) as an oil (4.7 g, 95% yield). Mass spectrometry (MS) analysis: (M + 1): 215.95.

References

[1] Patent: US2007/287695, 2007, A1. Location in patent: Page/Page column 14; 55
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132

(1R,2R)-trans-N-Boc-2-Aminocyclohexanol(155975-19-2)Related Product Information

• tert-butyl ((1R,2R)-2-(hydroxymethyl)cyclopentyl)carbamate
• N,N'-BIS-BOC-1-GUANYLPYRAZOLE
• tert-butyl ((1R,2S)-2-(aminomethyl)cyclopentyl)carbamate
• (1R,3S)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester
• Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• Carbamic acid, N-[(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester, hydrochloride (1:1)