Madecassoside Chemical Properties

Melting point:

220-223 °C

Boiling point:

1043.6±65.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble1mg/mL, clear, colorless

pka

12.50±0.70(Predicted)

form 

powder

color 

white to off-white

Stability:

Hygroscopic

InChIKey

BNMGUJRJUUDLHW-CIZDPPTDSA-N

LogP

-1.338 (est)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

YU9555000

HS Code 

29389090

Madecassoside Usage And Synthesis

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.

Madecassoside(34540-22-2)Related Product Information

• Asiaticoside
• Centella asiatica extract
• Total Of Triterpenes
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• 1,12-OCTADECANEDIOL
• isobutoxypropanol
• 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE
• isohexadecanoic acid
• 2-Ethyl-1,3-hexanediol
• MONOLAURIN
• MONOCAPRYLIN
• Isopropyl-cyclohexanecarboxylic acid
• METHYL 15-HYDROXYPENTADECANOATE
• 15-HYDROXYPENTADECANOIC ACID
• N-PENTADECANOIC ACID ETHYL ESTER
• ETHYL 2,2-DIETHYLBUTYRATE
• 1,3-DIISOPROPYLCYCLOHEXANE