4-Chlorophenylacetone Chemical Properties

Melting point:

6-8 °C

Boiling point:

132 °C

Density 

1.151

refractive index 

1.5325-1.5345

Flash point:

>110℃

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear light yellow

CAS DataBase Reference

5586-88-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanone,p-chlorophenyl-(5586-88-9)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-52

Safety Statements 

24/25

HS Code 

29147000

MSDS

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4-Chlorophenylacetone Usage And Synthesis

Chemical Properties

clear light yellow liquid

Uses

4-Chlorophenylacetone is a phenylacetone derivative used in the preparation of biologically active compounds such as anorectic agents.

Preparation

At present, there are three main synthetic routes for 4-chlorophenylacetone. The first is to synthesize 4-chlorophenylacetone with sodium p-chlorobenzenesulfonate and acetone as raw materials, with a yield of about 54%. The second synthesis route is to synthesize 4-chlorophenylacetone with p-chlorobenzenesulfonyl chloride and chloroacetone as raw materials. The third synthesis route is to synthesize 4-chlorophenylacetone from chloroacetone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 2590, 1983 DOI: 10.1021/jo00163a034

Health Hazard

When it contacts with skin and mucous membrane, 4-chlorophenylacetone will cause inflammation, so pay attention to safety when using 4-chlorophenylacetone. This chemical is harmful to environment. It should be prevented from contacting groundwater, waterways or sewage systems. Without government permission, 4-chlorophenylacetone should not be discharged into the surrounding environment.

4-Chlorophenylacetone(5586-88-9)Related Product Information

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