transfer factor (TF) Usage And Synthesis

Chemical Properties

Soluble, dialyzable, ultrafilterable, freeze-dried. The properties are stable at low temperature (-20°C), and it will not lose its activity after cryopreservation for more than 45 years. But not heat-resistant, 56 ℃, 30min inactivation. Not destroyed by Rnase, Dnase, trypsin, lysozyme. The maximum wavelength of ultraviolet light absorption is 250-260nm.

Uses

Transfer factor (TF) can promote the release of interferon. It is clinically used to treat diseases related to weakened or defective cellular immunity, such as leprosy, systemic vaccinia, Candida albicans infection, intracellular infection caused by virus, bacteria or mold, malignant tumor, rheumatoid arthritis, etc.

Preparation

Dialysis method
Wash the spleen, remove the membrane, tendons and fat, wash with cold heavy distilled water, cut into pieces, add the same amount of distilled water, smash it, and after microscopic examination, most of the lymphocytes have been broken, and store at -30℃ Freeze, thaw in a 37°C water bath, freeze and thaw repeatedly for 6-8 times, freeze and centrifuge for 20 min, take the supernatant, and dialyze the supernatant in a 4°C refrigerator for 48 hours to obtain TF.

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