(R)-(+)-SKF-38393 hydrochloride Chemical Properties

Melting point:

244-246 °C

solubility 

0.1 M HCl: soluble1.2mg/mL

form 

solid

color 

off-white to light tan

optical activity

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-22

WGK Germany 

3

(R)-(+)-SKF-38393 hydrochloride Usage And Synthesis

Uses

(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist.

Uses

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects.