5-METHYL-2-(TRIFLUOROMETHYL)ANILINE Chemical Properties

Boiling point:

207.2±35.0 °C(Predicted)

Density 

1.237±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

pka

1.59±0.10(Predicted)

Appearance

Yellow to brown Liquid

Water Solubility 

Slightly soluble in water.

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

2810

HazardClass 

6.1

HS Code 

2921420090

5-METHYL-2-(TRIFLUOROMETHYL)ANILINE Usage And Synthesis

Synthesis

Step 1: 4-methyl-2-nitro-1-trifluoromethylbenzene (1 g, 4.8 mmol) and 30 mL of methanol were added to a 100 mL reaction vial. Pd/C catalyst (0.2 g, 10% content) was then added. The reaction mixture was stirred under hydrogen atmosphere (1 atm, 25°C) for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/petroleum ether = 1:10) to afford 2-amino-4-methylbenzotrifluoride (0.68 g, 80% yield). Mass spectrometry analysis: [M+1]+ 176.2.

References

[1] Patent: EP3150592, 2017, A1. Location in patent: Paragraph 0133; 0134; 0135
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3738 - 3743

5-METHYL-2-(TRIFLUOROMETHYL)ANILINE(106877-29-6)Related Product Information

• 2,5-Bis(trifluoromethyl)nitrobenzene
• 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID
• 2,5-bis(trifluoromethyl)-phenyhydrazine
• 2-AMINO-3-CHLORO-5-CYANOBENZOTRIFLUORIDE
• Dutasteride
• 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE
• 2,5-Bis(trifluoromethyl)aniline
• 2-METHYL-3-(TRIFLUOROMETHYL)ANILINE
• 3-NITRO-4-(TRIFLUOROMETHYL)BENZOIC ACID
• 2-FLUORO-3-METHYL-6-(TRIFLUOROMETHYL)PHENYLHYDRAZINE
• 2,3,4,5,6-PENTAKIS(TRIFLUOROMETHYL)ANILINE
• 1-CHLORO-4-NITRO-2,5-BIS(TRIFLUOROMETHYL)BENZENE
• 2-METHOXY-3-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE
• 3-(2,5-BIS-TRIFLUOROMETHYL-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
• 4-CHLORO-2-FLUORO-3-METHYL-6-(TRIFLUOROMETHYL)ANILINE
• 2-METHOXY-5-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE
• AMINO-(3-NITRO-4-TRIFLUOROMETHYL-PHENYL)-ACETIC ACID
• 2,5-BIS(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE