3-Fluoro-4-methylpyridine Chemical Properties

Boiling point:

135,6 C

Density 

1.08 g/cm

refractive index 

1,479

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

pka

3.48±0.18(Predicted)

color 

Colorless to pale yellow

CAS DataBase Reference

399-88-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

1993

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

2933399990

3-Fluoro-4-methylpyridine Usage And Synthesis

Synthesis

3-Fluoro-4-methylpyridine To a cooled (-78℃) solution of N, N-diisopropylamine (15.92mL, 113.4mmol) in THF (14OmL) a solution of BuLi 2.5M in hexane (45.4ml, 113.4 mmol) was added dropwise over 30 minutes under an atmosphere of Argon. The mixture was stirred for 30 min. at - 78℃ and a solution of 3-fluoropyridine (10g, 103.1 mmol) in THF (5ml) was added. After 1h at -780C, the mixture was treated with MeI (7 ml, 113.4mmol) and then was allowed to reach 250C. A solution of NaHCO3 saturated (30ml) was added and the aqueous phase was extracted with diethyl ether. The organic layer was dried (MgSO4) and upon distillation the product was collected as a colourless liquid 3-Fluoro-4-methylpyridine, bp 1300C, yield 5.3 g (47percent).

3-Fluoro-4-methylpyridine(399-88-2)Related Product Information

• Methyl propyl carbonate
• 2-Chloro-5-chloromethylpyridine
• 3-(Trifluoromethyl)benzaldehyde
• 4-Methylpyridine
• Flupirtine
• 3-Fluoropyridine
• 2,4,6-Collidine
• Azamethiphos
• 2,6-Lutidine
• 2-(Trifluoromethyl)benzoic acid
• 2,3,6-TRIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
• 2-AMINO-3,6-DIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
• 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&
• 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID, 97
• 2,6-DIBROMO-3,5-DIFLUOROISONICOTINIC ACID
• 2,3,6-TRIFLUOROISONICOTINIC ACID
• 3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
• Fluorine