P-HYDROXYMETHAMPHETAMINE
P-HYDROXYMETHAMPHETAMINE Basic information
- Product Name:
- P-HYDROXYMETHAMPHETAMINE
- Synonyms:
-
- 1-(p-hydroxyphenyl)-2-methylaminopropane
- 1-(p-oxyphenyl)-2-methylaminopropan
- alpha-(p-hydroxyphenyl)-beta-methylaminopropane
- alpha-(p-oxyphenyl)-beta-methylaminopropane
- beta-(p-hydroxyphenyl)isopropylmethylamine
- beta(p-oxy-phenyl)isopropylmethylamin
- epifen
- foledrin
- CAS:
- 370-14-9
- MF:
- C10H15NO
- MW:
- 165.23
- EINECS:
- 206-725-0
- Product Categories:
-
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 370-14-9.mol
P-HYDROXYMETHAMPHETAMINE Chemical Properties
- Melting point:
- 162-163°
- Boiling point:
- 293.09°C (rough estimate)
- Density
- 1.0203 (rough estimate)
- refractive index
- 1.4820 (estimate)
- storage temp.
- −20°C
- solubility
- Methanol (Slightly)
- pka
- 9.82±0.15(Predicted)
Safety Information
- Hazard Codes
- Xi,T,F
- Risk Statements
- 36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36-45-36/37-16-7
- WGK Germany
- 3
- RTECS
- SL8400000
- Toxicity
- LD50 parenteral in mouse: 100mg/kg
P-HYDROXYMETHAMPHETAMINE Usage And Synthesis
Chemical Properties
Off-White Solid
Originator
Pholedrine Sulfate, ZYF Pharm Chemical
Uses
An a-adrenergic agonist. Antihypotensive.
Definition
ChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process
100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic Function
Sympathomimetic, Mydriatic, Analeptic, Vasopressor
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