2-MONOPALMITIN Chemical Properties

Melting point:

68-70°C

Boiling point:

387.92°C (rough estimate)

Density 

0.9708 (rough estimate)

refractive index 

1.4434 (estimate)

storage temp. 

−20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

13.54±0.10(Predicted)

form 

Solid

color 

White to Off-White

BRN 

1796692

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

WGK Germany 

3

2-MONOPALMITIN Usage And Synthesis

Description

2-Arachidonoyl glycerol (2-AG; ) is an endogenous agonist of the CB₁ and CB₂ cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB₁ and CB₂ and inhibit adenylyl cyclase. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.

Chemical Properties

White Solid

Uses

A biomarker of metabolic responses to hepatotoxicants and carcinogens.

Definition

ChEBI: A 2-monoglyceride where the acyl group is hexadecanoyl (palmitoyl).

Biological Activity

Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol ((5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester ). Does not bind to CB 1 or CB 2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

2-MONOPALMITIN(23470-00-0)Related Product Information

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