2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Basic information
- Product Name:
- 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
- Synonyms:
-
- 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
- TMPH HYDROCHLORIDE
- 2,2,6,6-Tetramethylpiperidin-4-ylheptanoate
- Heptanoic acid, 2,2,6,6-tetramethyl-4-piperidinyl ester
- TMPH
- neurol disorder,nAChR,Nicotinic acetylcholine receptors,neuronal nicotinic receptors,selective inhibition,Inhibitor,inhibit,nicotinic receptor,brain function,tetramethylpiperidinyl heptanoate,dysfunction
- TMPH inhibitor
- TMPH, 10 mM in DMSO
- CAS:
- 849461-90-1
- MF:
- C16H31NO2
- MW:
- 269.42
- Mol File:
- 849461-90-1.mol
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- H2O: 22 mg/mL at ~60 °C
- form
- solid
- color
- white
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37
MSDS
- Language:English Provider:SigmaAldrich
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Usage And Synthesis
Uses
TMPH Hydrochloride is a potent inhibitor of neuronal AChRs. Therapeutic agent potentially used for the treatment of this progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease.
Definition
ChEBI: Heptanoic acid (2,2,6,6-tetramethyl-4-piperidinyl) ester is a fatty acid ester.
Biological Activity
Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α 3, α 4 and β 2, β 4 respectively). Displays little inhibition of muscle-type ( α 1 β 1 γ δ ) or α 7 receptors.
in vivo
nAChR-IN-1 (20 mg/kg; s.c.; single dose) improves nicotine-induced hypomotility and hypothermia in a time-dependent manner in mice[1].
| Animal Model: | Nicotine-induced mice model[1] |
| Dosage: | 20 mg/kg |
| Administration: | Subcutaneous injection; single dose; 15 minutes prior to the injection of nicotine (1.5 mg/kg)? |
| Result: | Increased locomotor activity in mice, even if nicotine-induced decrease. Showed no effect on body temperature. |
| Animal Model: | Tail-flick and hot-platemodel in mice[1] |
| Dosage: | 0, 0.1, 1, 5 mg/kg |
| Administration: | Subcutaneous injection; single dose |
| Result: | Blocked the antinociceptive effect of nicotine in the hot-plate. Time-dependently blocked nicotine-induced antinociception. |
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDESupplier
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