Basic information Safety Supplier Related

N'-NITROSONORNICOTINE

Basic information Safety Supplier Related

N'-NITROSONORNICOTINE Basic information

Product Name:
N'-NITROSONORNICOTINE
Synonyms:
  • 1’-demethyl-1’-nitroso-nicotin
  • 1’-desmethyl-1’-nitrosonicotine
  • 1’-nitroso-1’-demethyl-nicotin
  • 1’-nitroso-1’-demethylnicotine
  • 1’-nitrosonornicotine
  • 1-nitroso-2-(3-pyridyl)pyrrolidine
  • nitrosonornicotine
  • -Nitrosonornicotine-d4
CAS:
16543-55-8
MF:
C9H11N3O
MW:
177.2
Product Categories:
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Nicotine Derivatives
Mol File:
16543-55-8.mol
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N'-NITROSONORNICOTINE Chemical Properties

Melting point:
47.1°C
Boiling point:
309.13°C (rough estimate)
Density 
1.1669 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
5.16±0.12(Predicted)
color 
Off-White to Pale Beige
Stability:
Stable, but air and light sensitive. Incompatible with oxidizing agents.
IARC
1 (Vol. Sup 7, 89, 100E) 2012
EPA Substance Registry System
N-Nitrosonornicotine (16543-55-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
36/37/38-40
Safety Statements 
26-36
RIDADR 
2810
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
16543-55-8(Hazardous Substances Data)
Toxicity
LD50 intraperitoneal in mouse: 1gm/kg
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N'-NITROSONORNICOTINE Usage And Synthesis

Description

A nicotine alkaloid, this base has been detected in some Japanese cigarette tobaccos and also in Kirsu tobacco where it occurs in the fresh leaves that have been dried without fermentation. From these two sources it has been isolated at 1.1 and 1. 8 ppm levels respectively

Chemical Properties

white crystals

Uses

A tobacco alkaloid as risk factor of human cancer.

General Description

White crystalline flakes or yellow oil that solidifies on standing in the cold.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated amine, nicotine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition it may emit toxic and hazardous fumes of NOx and COx.

Fire Hazard

Flash point data for N'-NITROSONORNICOTINE are not available; however, N'-NITROSONORNICOTINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Low toxicity by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosonornicotine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

References

Bharadwaj et al., Gann., 66, 585 (1975)

N'-NITROSONORNICOTINESupplier

guoyungurui Gold
Tel
18162595016; 18162595016
Email
3287908757@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
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