Diethylacetamide Chemical Properties

Melting point:

<20 °C

Boiling point:

182-186 °C (lit.)

Density 

0.925 g/mL at 25 °C (lit.)

vapor pressure 

1.2 hPa (25 °C)

refractive index 

n20/D 1.440(lit.)

Flash point:

159 °F

storage temp. 

Store below +30°C.

solubility 

53.5g/l

pka

-0.41±0.70(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

Water Solubility 

Soluble in water.

BRN 

1209428

Dielectric constant

31.329999999999998

CAS DataBase Reference

685-91-6(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, N,N-diethyl-(685-91-6)

EPA Substance Registry System

N,N-Diethylacetamide (685-91-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-27-36/37/39-45

WGK Germany 

3

RTECS 

AB7000000

TSCA 

Yes

HS Code 

29241900

Hazardous Substances Data

685-91-6(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 1500 mg/kg

MSDS

• Language:English Provider:Diethylacetamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Diethylacetamide Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

N,N-Diethylacetamide was used to investigate the spectroscopic properties ofN,N-diethyl-2-[(4-substituted)phenylsulfinyl] acetamides. It is commonly used as drug solvent.

Synthesis Reference(s)

Chemistry Letters, 18, p. 1983, 1989
The Journal of Organic Chemistry, 59, p. 4035, 1994 DOI: 10.1021/jo00094a004

General Description

N,N-Diethylacetamide is commonly used as drug solvent.

Hazard

Toxic by ingestion.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Flammable when exposed to heat or flame. To fight fire, use foam, mist, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dissolve the amide in cyclohexane, shake with anhydrous BaO and then filter. The procedure is repeated three times, and the cyclohexane is distilled off at atmospheric pressure. The crude amide is also fractionally distilled three times from anhydrous BaO. [Beilstein 4 III 349.]

Diethylacetamide(685-91-6)Related Product Information

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• N,N-Diethylethylenediamine
• 2-Cyano-N,N-diethylacetamide
• N,N-Dimethylacetoacetamide
• N-Phthaloylglycine
• PHTHALIMIDOACETALDEHYDE DIETHYL ACETAL
• N-Hydroxyethylphthalimide
• 2-Chloro-N,N-diethylacetamide
• 1-(3-AMINOPROPYL)-2-PYRROLIDINONE
• 1-Benzyl-2-pyrrolidinone
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• OXOTREMORINE
• N-(2-Bromoethyl)phthalimide
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• Actinomycin D
• N-Ethylmaleimide
• N,N-Diethylcyanoacetamide
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