Triprolidine hydrochloride Chemical Properties

Melting point:

115-120°C

storage temp. 

2-8°C

solubility 

alcohol: soluble1 in 1.5 of solvent

color 

White to Off-White

Water Solubility 

>=10 g/100 mL at 20 ºC

Merck 

13,9817

Stability:

Stable, but discolours in light. Incompatible with strong oxidizing agents.

LogP

4.223 (est)

CAS DataBase Reference

6138-79-0(CAS DataBase Reference)

EPA Substance Registry System

Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

UT7658000

HS Code 

2933399090

MSDS

• Language:English Provider:(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

Triprolidine hydrochloride Usage And Synthesis

Chemical Properties

TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.

Uses

anticholinergic (opthalmic)

Uses

trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.

Uses

TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Definition

TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

General Description

Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.

General Description

Odorless white crystalline powder. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Triprolidine hydrochloride discolors on exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.

Fire Hazard

Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.

Biological Activity

Potent H 1 receptor antagonist.

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