MYRISTOYL-ARG-LYS-ARG-THR-LEU-ARG-ARG-LEU-OH Chemical Properties

storage temp. 

-20°C

form 

Solid

color 

White to off-white

Sequence

{Myr}-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu

MYRISTOYL-ARG-LYS-ARG-THR-LEU-ARG-ARG-LEU-OH Usage And Synthesis

Uses

N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca2+- and phosphatidylserine (PS)-dependent histone phosphorylation with IC50 of 5 μM. histone phosphorylation with IC50 of 80 μM[1][2].

References

[1] David K Crockett, et al. Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest. 2005 Nov;85(11):1405-15. DOI:10.1038/labinvest.3700343
[2] C A O'Brian, et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to Adriamycin. Invest New Drugs. 1991 May;9(2):169-79. DOI:10.1007/BF00175084

MYRISTOYL-ARG-LYS-ARG-THR-LEU-ARG-ARG-LEU-OH(152246-40-7)Related Product Information

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