ISOCORYDINE HYDROCHLORIDE
ISOCORYDINE HYDROCHLORIDE Basic information
- Product Name:
- ISOCORYDINE HYDROCHLORIDE
- Synonyms:
-
- LUTEANINE
- LUTEANINE HYDROCHLORIDE
- 1,2,10-trimethoxy-6a-alpha-aporphin-11-o
- 4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy
- artabotrin
- d-isocorydine
- l-(+)-isocorydine
- luteanin
- CAS:
- 475-67-2
- MF:
- C20H23NO4
- MW:
- 341.4
- Product Categories:
-
- Inhibitors
- Miscellaneous Natural Products
- Alkaloids
- Mol File:
- 475-67-2.mol
ISOCORYDINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 216-220 °C(lit.)
- alpha
- D20 +195° (chloroform)
- Boiling point:
- 477.03°C (rough estimate)
- Density
- 1.2064 (rough estimate)
- refractive index
- 1.5614 (estimate)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Cryst.
- pka
- 9.41±0.20(Predicted)
ISOCORYDINE HYDROCHLORIDE Usage And Synthesis
Description
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
Uses
Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.
Uses
sedative, cholinergic
Uses
Isocorydine is an alkaloid inhibitor of eukaryotic kinases.
Definition
ChEBI: Isocorydine is an aporphine alkaloid.
target
Dopamine Receptor | P450 (e.g. CYP17)
References
See Isocorydine
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ISOCORYDINE HYDROCHLORIDE(475-67-2)Related Product Information
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