CANGRELOR
CANGRELOR Basic information
- Product Name:
- CANGRELOR
- Synonyms:
-
- CANGRELOR
- N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid anhydride with P,P'-(dichloromethylene)bis[phosphonic acid]
- AR-C69931 (Cangrelor)
- Cangrelor (AR-C69931)
- Kengreal
- 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine
- Cangrelor sodium
- [dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid
- CAS:
- 163706-06-7
- MF:
- C17H25Cl2F3N5O12P3S2
- MW:
- 776.36
- EINECS:
- 1592732-453-0
- Product Categories:
-
- API
- Pharmaceutical
- Mol File:
- 163706-06-7.mol
CANGRELOR Chemical Properties
- Boiling point:
- 979.0±75.0 °C(Predicted)
- Density
- 2.08
- pka
- 0.82±0.50(Predicted)
- InChIKey
- PAEBIVWUMLRPSK-NJLALLTJNA-N
- SMILES
- P(O)(=O)(OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O1)N1C=NC2C(NCCSC)=NC(SCCC(F)(F)F)=NC1=2)C(Cl)(Cl)P(O)(O)=O |&1:9,10,12,14,r|
Safety Information
- Hazardous Substances Data
- 163706-06-7(Hazardous Substances Data)
CANGRELOR Usage And Synthesis
Uses
Anti-platelet agent.
Uses
Cangrelor is a P2Y12 inhibitor used as an antiplatelet drug for intravenous application.
Definition
ChEBI: A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.
Clinical Use
Direct P2Y12 platelet receptor antagonist:
Antiplatelet for patients undergoing a PCI
in vivo
Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2].
IC 50
P2Y12 Receptor
Metabolism
Cangrelor is deactivated rapidly in the plasma by dephosphorylation to form its main metabolite, a nucleoside. Following a 2 micrograms/kg/min infusion of [3 H] cangrelor, 58% was found in urine and the remaining 35% was found in faeces, presumably following biliary excretion.
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