Basic information Safety Supplier Related

ESCIN IIB

Basic information Safety Supplier Related

ESCIN IIB Basic information

Product Name:
ESCIN IIB
Synonyms:
  • AESCIN IIB
  • ESCIN IIB
  • 06035642G6
  • b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-
  • β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
  • EscinID
CAS:
158800-83-0
MF:
C54H84O23
MW:
1101.23
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
158800-83-0.mol
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ESCIN IIB Chemical Properties

Boiling point:
1111.9±65.0 °C(Predicted)
Density 
1.45±0.1 g/cm3 (20 ºC 760 Torr)
pka
2.63±0.70(Predicted)
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ESCIN IIB Usage And Synthesis

Uses

Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals[1]. Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions[2].

in vivo

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions[2].

Animal Model:Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[2]
Dosage:P.o.
Administration:10-50 mg/kg
Result:Showed a potent protective effect against ethanol-induced gastric lesions in rats.

References

[1] Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. DOI:10.1248/bpb.20.1092
[2] Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. DOI:10.1016/s0014-2999(99)00249-6

ESCIN IIBSupplier

AdooQ BioScience, LLC
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Shanghai BeiZhuo Biotech Co., Ltd.
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Shanghai Yongye Biotechnology Co., Ltd.
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Nanjing Duolong Bio-tech Co.,Ltd.
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18905173768
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ALB Technology Limited
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702-983-3769
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ESCIN IIB(158800-83-0)Related Product Information