2-BROMO-5-NITROPYRIDIN-4-AMINE Chemical Properties

Boiling point:

396.3±37.0 °C(Predicted)

Density 

1.929±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.79±0.42(Predicted)

Appearance

Light yellow to light brown Solid

Safety Information

HS Code 

2933399990

2-BROMO-5-NITROPYRIDIN-4-AMINE Usage And Synthesis

Synthesis

Step 1. 2,4-Dibromo-5-nitropyridine (3.67 g) was dissolved in tetrahydrofuran (THF, 150 mL) under the protection of nitrogen, followed by the addition of methanol solution of ammonia (2 M) and triethylamine (5 mL) sequentially. The reaction mixture was stirred at room temperature for 50 hours. Upon completion of the reaction, the reaction mixture was concentrated, the residue was dissolved in ethyl acetate (EtOAc), filtered through a silica gel pad, and the filtrate was concentrated under vacuum to afford 2-bromo-5-nitro-4-aminopyridine in 95% yield.

References

[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 102

2-BROMO-5-NITROPYRIDIN-4-AMINE(84487-15-0)Related Product Information

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