Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Ethyl 4,6-dichloropyrridazine-3-carboxylate

Ethyl 4,6-dichloropyrridazine-3-carboxylate

Basic information Safety Supplier Related

Ethyl 4,6-dichloropyrridazine-3-carboxylate Basic information

Product Name:
Ethyl 4,6-dichloropyrridazine-3-carboxylate
Synonyms:
  • 4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester
  • ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
  • EOS-61510
  • 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
  • 3-Pyridazinecarboxylic acid, 4,6-dichloro-, ethyl ester
  • Ethyl 4,6-dichloropyrridazine-3-carboxylate
  • 4,6-Dichloropyrazine-3-carboxylic acid ethyl ester
  • Ethyl 4,6-dichloro-3-pyridazinecarboxylate
CAS:
679406-03-2
MF:
C7H6Cl2N2O2
MW:
221.04
Mol File:
679406-03-2.mol
More
Less

Ethyl 4,6-dichloropyrridazine-3-carboxylate Chemical Properties

Boiling point:
353.4±37.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Acetonitrile (Slightly), Chloroform (Soluble), Methanol (Slightly)
pka
-2.18±0.10(Predicted)
form 
Low-Melting Solid
color 
Brown to Very Dark Brown
More
Less

Ethyl 4,6-dichloropyrridazine-3-carboxylate Usage And Synthesis

Uses

Ethyl 4,6-Dichloropyridazine-3-carboxylate is a useful reagent for the green preparation of Deucravacitinib, a deuterated API for TYK2 Inhibition.

Synthesis

To a 350 mL nitrogen purged Schlenk flask containing Ethyl 4,6-dihydroxypyridazine-3-carboxylate (3.77 g, 20.47 mmol) was added phosphorus oxychloride (38 mL, 408 mmol). The vessel was sealed and heated to 100 °C for 3.5 hours. The reaction was cooled to room temperature and the excess phosphorus oxychloride was removed in vacuo. The crude oil was dissolved into chloroform, re-concentrated and then poured into ice water, rinsing with ethyl acetate.The two layers were transferred to a separatory funnel, separated and the aqueous layer extracted 3x with ethyl acetate. The combined organic layers were washed twice with water and once with brine (saturated aqueous sodium chloride) and then dried over sodium sulfate, filtered, concentrated and then purified by automated chromatography (5- 90percent EtOAc:hexanes), providing Ethyl 4,6-dichloropyrridazine-3-carboxylate (3.64 g, 16.3 mmol). ‘H NMR (400MHz, chloroform-d) ? 7.70 (s, 1H), 4.55 (qd, J=7.1, 1.1 Hz, 2H), 1.46 (td, J=7.2, 0.9 Hz, 3H).

Ethyl 4,6-dichloropyrridazine-3-carboxylateSupplier

Hangzhou Chemtrue Bio-Tech Co.,Ltd. Gold
Tel
0571-86828652 18857119830
Email
sales@chemtrue-bio.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Email
sales@jingyan-chemical.com
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Email
info4@huanlingchem.com
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Email
isenchem@163.com
More
Less

Ethyl 4,6-dichloropyrridazine-3-carboxylate(679406-03-2)Related Product Information