2,6-Dichloro-7-methylpurine Chemical Properties

Melting point:

195.5-196 °C

Boiling point:

307.2±52.0 °C(Predicted)

Density 

1.76±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.04±0.30(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

2273-93-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

HazardClass 

IRRITANT

2,6-Dichloro-7-methylpurine Usage And Synthesis

Uses

2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.

Synthesis

A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield).

References

[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7

2,6-Dichloro-7-methylpurine(2273-93-0)Related Product Information

• Dichloromethylsilane
• 2,6-Dichloropurine
• 2-Chloro-5-chloromethylpyridine
• Methyl acrylate
• Methyl acetate
• Methylparaben
• Dichlorodimethylsilane
• Purine
• Bensulfuron methyl
• Dichloromethylphenylsilane
• Kresoxim-methyl
• Thiophanate-methyl
• 6-O-Methyl-guanine
• Methyl
• Parathion-methyl
• Methyl bromide
• 2-Chloropyrimidine
• 2-Chloropurine