MECLOCYCLINE SULFOSALICYLATE SALT Chemical Properties

Melting point:

>193°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

methanol: soluble10ML, clear, very dark yellow (200 mg + 10 mL MeOH)

form 

Solid

color 

yellow-green powder

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

HS Code 

2941300000

MSDS

• Language:English Provider:SigmaAldrich

MECLOCYCLINE SULFOSALICYLATE SALT Usage And Synthesis

Uses

Antibacterial;Antibacterial

Uses

Meclocycline Sulfosalicylate Salt is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in solution with 2-hydroxy-3-carboxybenenesulphonic acid. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. The unusual complex counter-ion is likely to add an antiseptic component to the use of the compound for skin infections.

Uses

Meclocycline is a tetracycline antibiotic that is topically used for skin infections and irritations.

brand name

Meclan (Johnson & Johnson).

General Description

Meclocycline, 7-chloro-6-deoxy-6-demethyl-6-methylene-5-oxytetracycline sulfosalicylate (Meclan), is a semisyntheticderivative prepared from oxytetracycline.Although meclocycline has been used in Europe for manyyears, it became available only relatively recently in theUnited States for a single therapeutic indication, the treatmentof acne. It is available as the sulfosalicylate salt in a1% cream.
Meclocycline sulfosalicylate is a bright yellow, crystallinepowder that is slightly soluble in water and insolublein organic solvents. It is light sensitive and should be storedin light-resistant containers.

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