Basic information Safety Supplier Related

CX-4945

Basic information Safety Supplier Related

CX-4945 Basic information

Product Name:
CX-4945
Synonyms:
  • 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid
  • CX-4945
  • Silmitasertib
  • CX-4945 Silmitasertib
  • CX-4945, CX4945
  • Silmitasertib(CX-4945)
  • 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)
  • CX-4945, >=98%
CAS:
1009820-21-6
MF:
C19H12ClN3O2
MW:
349.77
Product Categories:
  • Inhibitors
Mol File:
1009820-21-6.mol
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CX-4945 Chemical Properties

Boiling point:
568.5±50.0 °C(Predicted)
Density 
1.490
solubility 
≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Orange powder.
pka
2.96±0.30(Predicted)
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Safety Information

HS Code 
29339900
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CX-4945 Usage And Synthesis

Uses

CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.

Biological Activity

cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]

References

[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.

CX-4945Supplier

Lancrix Chemicals Gold
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86-21-50817262
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Wuxi KaideRui Pharmaceutical Technology Co., Ltd Gold
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15370852968
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1557216087@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd. Gold
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15076683720
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klq@cw-bio.com
Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
Chembest Research Laboratories Limited
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