Met-RANTES (human) Chemical Properties

Sequence

Met-Ser-Pro-Tyr-Ser-Ser-Asp-Thr-Thr-Pro-Cys-Cys-Phe-Ala-Tyr-Ile-Ala-Arg-Pro-Leu-Pro-Arg-Ala-His-Ile-Lys-Glu-Tyr-Phe-Tyr-Thr-Ser-Gly-Lys-Cys-Ser-Asn-Pro-Ala-Val-Val-Phe-Val-Thr-Arg-Lys-Asn-Arg-Gln-Val-Cys-Ala-Asn-Pro-Glu-Lys-Lys-Trp-Val-Arg-Glu-Tyr-Ile-Asn-Ser-Leu-Glu-Met-Ser (Disulfide bridge: Cys11-Cys35, Cys12-Cys51)

Met-RANTES (human) Usage And Synthesis

Uses

Met-RANTES (human) is the antagonist for CCR1 and CCR5. Met-RANTES (human) inhibits chemokines human MIP-1α and MIP-1β with IC50 of 5 and 2 nM. Met-RANTES (human) reduces bone destruction and ameliorates rats adjuvant-induced arthritis (AIA)[1].

IC 50

CCR5; CCR1

References

[1] Shahrara S, et al., Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum. 2005 Jun;52(6):1907-19. DOI:10.1002/art.21033

Met-RANTES (human)(1883816-50-9)Related Product Information

• H-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-ARG-ARG-ARG-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-NH2
• 11-Dideuterolinoleic acid
• IKKγ NBD Inhibitory Peptide
• GALANIN-(2-13)-GLU-HIS-(PRO)3-(ALA-LEU)2-ALA-AMIDE
• RAGE antagonist peptide
• ALPHA-CGRP (8-37) (RAT)