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PROTRIPTYLINE HYDROCHLORIDE

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PROTRIPTYLINE HYDROCHLORIDE Basic information

Product Name:
PROTRIPTYLINE HYDROCHLORIDE
Synonyms:
  • concordin
  • d)cyclohepten-5-propylamine,n-methyl-5h-dibenzo(hydrochloride
  • maximed
  • mk-240
  • n-methyl-5h-dibenzo(a,d)cycloheptene-5-propylaminehydrochloride
  • normethylex4442
  • triptilhydrochloride
  • Protriptylin hydrochloride
CAS:
1225-55-4
MF:
C19H22ClN
MW:
299.84
EINECS:
214-956-3
Product Categories:
  • Biogenic Amine Transport Inhibitors
  • Biogenic Amine Transport InhibitorsObesity Research
  • Neurotransmission
  • Neurotransmission (Obesity)
  • Neurotransmitters
Mol File:
1225-55-4.mol
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PROTRIPTYLINE HYDROCHLORIDE Chemical Properties

Melting point:
169-171°
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL
pka
8.2(at 25℃)
form 
powder
color 
white to off-white
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-45-36/37-16-7
RIDADR 
3249
WGK Germany 
3
RTECS 
HP1400000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2921490002
Toxicity
dog,LDLo,oral,400mg/kg (400mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.
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PROTRIPTYLINE HYDROCHLORIDE Usage And Synthesis

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

brand name

Vivactil (Odyssey).

General Description

Protriptyline hydrochloride, N-methyl-5H-dibenzo[a,d]-cycloheptene-5-propylamine hydrochloride, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride(Vivactil), like the other compounds under consideration, isan effective antidepressant. The basis for its chemical namingcan be seen by consulting the naming and the structureof imipramine. Protriptyline is a structural isomer of nortriptyline.Inactivation can be expected to involve the relativelylocalized double bond. Because it is a monomethylcompound, its sedative potential is low.

Biochem/physiol Actions

Norepinephrine uptake blocker.

PROTRIPTYLINE HYDROCHLORIDESupplier

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