(S)-Ketorolac Chemical Properties

Melting point:

160-167?C

Boiling point:

493.2±40.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly

form 

A crystalline solid

pka

4.29±0.20(Predicted)

(S)-Ketorolac Usage And Synthesis

Description

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC₅₀s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.

Chemical Properties

Off-White Solid

Uses

The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Uses

(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Definition

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

(S)-Ketorolac(66635-92-5)Related Product Information

• Ketorolac Impurity 48
• rac Ketorolac 6-Benzoyl IsoMer
• 5-Benzoyl-2,3-Dihydro-Lh-Pyrrolizme-L,L-DicarboxyiicAcid,KetoralacTromethamine
• 2,2'-BIPYRROL
• Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)
• 1-Descarboxy Ketorolac
• Ketorolac EP IMpurity G
• Ketorolac Impurity 31
• 1-Keto Ketorolac
• (R)-(+)-Ketorolac
• Ketorolac Impurity 24
• (5-chloro-1H-pyrrol-2-yl)-phenylmethanone
• 4-HYDROXY KETOROLAC
• Ketorolac Impurity 43
• Ethyl 2-(1H-pyrrol-2-yl)acetate
• 3-BENZOYLPYRROLE
• Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol)
• Ketorolac tromethamine