Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Chemical Properties

Density 

1.54

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

form 

Solid

pka

13.59±0.20(Predicted)

color 

White to off-white

Sequence

Gly-Pro-Arg-Pro-Ala-NH2

InChIKey

BYWJFRMLHFQWSR-AJNGGQMLSA-N

SMILES

C(N)(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CN

Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Usage And Synthesis

Benifits for skin

Vialox, or Pentapeptide-3, is a synthetic peptide that acts on a different part of the neuromuscular junction. As a competitive antagonist at nicotinic acetylcholine receptors, Vialox prevents the sodium influx required for muscle fibers to depolarize and contract. Within one minute of treatment, muscle contracts can be reduced by up to 71%, and 58% of muscle fibers are still immotile two hours later. Vialox can prevent wrinkles from getting deeper due to muscle contractions. In one study, Vialox used twice a day for 28 days resulted in a nearly 50% reduction in wrinkle depth and roughness. It can be used at concentrations of 0.05%–0.3% to treat facial wrinkles and tighten skin.

Uses

Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides[1][2].

References

[1] Schagen, S.K. Topical peptide treatments with effective anti-aging results. Cosmetics 4(2), 2017.
[2] Zhmak MN, et al. Peptide inhibitors of nicotinic acetylcholine receptor. WO2014/112902Al, 2017.

Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide(135679-88-8)Related Product Information

• Acetyl Tetrapeptide-3
• Octapeptide 2
• Pentapeptide-25
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• Palmitoyl Pentapeptide
• Palmitoyl Tripeptide-5
• Acetyl Tetrapeptide-5
• Tripeptide-1
• (2S)-N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-2,4-diaminobutanoic acid bis(trifluoroacetate)
• Acetyl Dipeptide-1 cetyl ester
• MET-GLU-HIS-PHE-ARG-TRP-GLY
• Rigin
• Nonapeptide-1
• L-Carnosine
• H-SER-ILE-LYS-VAL-ALA-VAL-OH
• Palmitoyl Hexapeptide-12
• Argireline
• Dipeptide-2