3-Chloroisonicotinic acid Chemical Properties

Melting point:

227-231 °C (dec.)(lit.)

Boiling point:

387.0±22.0 °C(Predicted)

Density 

1.470±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

0.12±0.25(Predicted)

form 

Solution

color 

Brown to dark green to black

InChIKey

MYAZXWFEMDJTFE-UHFFFAOYSA-N

CAS DataBase Reference

88912-27-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333999

MSDS

• Language:English Provider:SigmaAldrich

3-Chloroisonicotinic acid Usage And Synthesis

Synthesis

A. Synthesis of 3-chloro-N-(4-chlorophenyl)pyridine-4-carboxamide. At -78 °C, 3-chloropyridine (1.00 mL, 10.5 mmol) was dissolved in THF and a freshly prepared lithium diisopropylammonium THF solution [prepared by the reaction of butyl lithium (7.21 mL, 11.5 mmol) with diisopropylamine (11.5 mmol)] was slowly added. After 0.25 h of reaction, carbon dioxide gas was passed into the mixture and slowly warmed to room temperature. After completion of the reaction, the mixture was concentrated and subsequently partitioned between EtOAc and water. The aqueous layer was washed twice with EtOAc. The pH of the aqueous layer was adjusted to about 3 by adding 1N HCl and extracted three more times with EtOAc. The organic phases were combined, dried with magnesium sulfate and concentrated. The residue was recrystallized by EtOAc to give 200 mg (12% yield) of 3-chloroisonicotinic acid.

References

[1] Patent: US6610704, 2003, B1

3-Chloroisonicotinic acid(88912-27-0)Related Product Information

• 4-Chlorophenyl isocyanate
• Chlorosulfonyl isocyanate
• Chlorobromoisocyanurate
• Ethyl 2-(Chlorosulfonyl)acetate
• Chloromethyl isopropyl carbonate
• Glycine
• Folic acid
• Isopropyl chloroformate
• Nicotinic acid
• Isobutyl chloroformate
• Isonicotinic acid
• Methyl isonicotinate
• 1-Chloro-2-methylpropane
• 2-Chloroisonicotinic acid ,97%,2-CHLORO-4-PYRIDINECARBOXYLIC ACID / 2-CHLOROISONICOTINIC ACID,2-CHLOROISONICOTINIC ACID
• 2,6-Dichloroisonicotinic acid
• 3,5-DICHLOROISONICOTINIC ACID
• 2-BROMO-3,5-DICHLOROISONICOTINIC ACID
• 2,5-Dichloroisonicotinic acid