4-METHOXYPHENYL ISOCYANIDE Chemical Properties

Melting point:

29-33 °C (lit.)

Boiling point:

113 °C

Flash point:

224 °F

storage temp. 

-20°C

Safety Information

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

UN 3335

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2929900090

MSDS

• Language:English Provider:SigmaAldrich

4-METHOXYPHENYL ISOCYANIDE Usage And Synthesis

Uses

4-Methoxyphenyl isocyanide can be used to synthesize N-(isoquinolin-1-yl)-formamides via reaction with 2-alkynylbenzaldoximes in the presence of silver trifluoromethanesulfonate and bismuth triflate.

Preparation

To an ice-cooled flask containing a solution of 10.5 gm (0.065 mole) of p-methoxyformanilide in 37.1 gm (0.47 mole) of pyridine and 13.0 ml (0.16 mole) of chloroform is added dropwise at 0°C 6.12 gm (0.040 mole) of phosphorus oxychloride. The solution is stirred for 1? hr at room temperature and then added to 55 ml of ice-water. The water layer is extracted with two 10-ml portions of chloroform; the combined chloroform layer is dried and distilled under reduced pressure, to afford 3.5 gm (40%), b.p. 767C (1.0 mm Hg), IR 2137 c m " 1 (R—NC).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 38, p. 2955, 1995 DOI: 10.1021/jm00015a018

4-METHOXYPHENYL ISOCYANIDE(10349-38-9)Related Product Information

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• 4-METHOXYPHENYL ISOCYANIDE
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• 2-NITRO-4-METHOXYPHENYL-ISOCYANIDE
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