Ethane, 1,2-bis(2-bromoethoxy)-
Ethane, 1,2-bis(2-bromoethoxy)- Basic information
- Product Name:
- Ethane, 1,2-bis(2-bromoethoxy)-
- Synonyms:
-
- Bromo-PEG2-bromide
- Br-PEG2-bromide
- Ethane, 1,2-bis(2-bromoethoxy)-
- Bromo-PEG3-bromide
- 1,2-Bis(2-bromoethoxy)ethane
- CAS_31255-10-4
- 1-bromo-2-[2-(2-bromoethoxy)ethoxy]ethane
- Br-PEG2-CH2CH2Br
- CAS:
- 31255-10-4
- MF:
- C6H12Br2O2
- MW:
- 275.97
- Mol File:
- 31255-10-4.mol
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Ethane, 1,2-bis(2-bromoethoxy)- Chemical Properties
- Boiling point:
- 140 °C(Press: 12 Torr)
- Density
- 1.6777 g/cm3
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform, Ethyl Acetate (Slightly)
- form
- Oil
- color
- Colourless
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C6H12Br2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2
- InChIKey
- UOWNEWCMPHICQH-UHFFFAOYSA-N
- SMILES
- C(OCCBr)COCCBr
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Ethane, 1,2-bis(2-bromoethoxy)- Usage And Synthesis
Description
Bromo-PEG2-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Chen TH, et al. Metal-organic frameworks constructed from crown ether-based 1,4-benzenedicarboxylic acid derivatives. Dalton Trans. 2016 Feb 21;45(7):3063-9. DOI:10.1039/c5dt04316f
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