1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Chemical Properties

Boiling point:

655.0±55.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

DMSO: >20mg/mL

form 

powder

pka

11.31±0.40(Predicted)

color 

orange

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

WGK Germany 

3

1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Usage And Synthesis

Description

BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC₅₀s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.

Definition

ChEBI: LSM-4550 is a member of anthracenes.

storage

Store at -20°C

References

1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099 2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194 3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon cancer cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191

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