Basic information Safety Supplier Related

(+)-Piresil-4-O-beta-D-glucopyraside

Basic information Safety Supplier Related

(+)-Piresil-4-O-beta-D-glucopyraside Basic information

Product Name:
(+)-Piresil-4-O-beta-D-glucopyraside
Synonyms:
  • (+)-Piresil-4-O-beta-D-glucopyraside
  • Pinoresinol 4-O-beta-D-glucopyranoside
  • Pinoresinol 4-O-glucoside
  • (+)-pinoresinol-β-D-glucoside
  • (+)-Piresil-4-O-β-D-glucopyraside
  • 3,5-dibromo-benzoic acid,3,5-dibromobenzoic acid
  • (+)-pinoresinol-4-O-β-D-glucopyranoside
  • (+)-pinoresinol-β-D-glucoside(+)-pinoresinol-4-O-beta-D-glucopyranoside
CAS:
69251-96-3
MF:
C26H32O11
MW:
520.53
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Lignans
Mol File:
69251-96-3.mol
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(+)-Piresil-4-O-beta-D-glucopyraside Chemical Properties

Melting point:
102-104 °C(Solv: methanol (67-56-1))
Boiling point:
752.5±60.0 °C(Predicted)
Density 
1.418±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
pka
9.84±0.35(Predicted)
color 
White to light yellow
InChIKey
QLJNETOQFQXTLI-DUAOPOKGNA-N
SMILES
O(C1=C(C=CC([C@H]2OC[C@]3([H])[C@@H](C4C=CC(O)=C(OC)C=4)OC[C@]23[H])=C1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C |&1:6,9,11,23,27,28,29,31,33,r|
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(+)-Piresil-4-O-beta-D-glucopyraside Usage And Synthesis

Chemical Properties

Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Forsythia.

Uses

(+)-Piresil-4-O-beta-D-glucopyraside is used for content determination/identification/pharmacological experiments, etc.

Definition

ChEBI: (+)-Pinoresinol 4-O-glucoside is a lignan and a glycoside.

Biological Activity

Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the main active furofuranoside lignan in Forsythia. It has antioxidant, hypotensive and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects.

in vivo

Pinoresinol 4-O-β-D-glucopyranoside (50 mg/kg; p.o.; 20 days for hepatoprotective activity test, 10 days for antihyperglycaemic activity test) exhibits hepatoprotective activity by lowering AST and ALT levels in CCl4 (HY-Y0298)-induced hepatotoxicity mice, and shows antihyperglycaemic activity by causing a prominent decline in serum glucose level and a promising elevation in insulin level in Streptozotocin (HY-13753)-treated mice[4].
Pinoresinol 4-O-β-D-glucopyranoside (25-50 mg/kg; p.o.; twice with the second dose 1 h before pilocarpine injection) ameliorates the seizures in a dose-dependent manner in lithium/Pilocarpine (HY-B0726A)-induced epileptic seizures rats, manifested by retarding seizure onset, reducing the number of rats developing seizures, and enhancing the survival of animals after seizure exposure[7].

Animal Model:Male Swiss albino mice (weight: 27-30 g), CCl4-induced hepatotoxicity model and Streptozotocin-induced hyperglycaemia model[4]
Dosage:50 mg/kg b.w.
Administration:Oral gavage (p.o.), 20 days in the hepatotoxicity experiment; 10 days in the hyperglycaemia experiment
Result:Led to a 33.94% decline in AST, a 3.01% decline in ALT, and a 49.96% decline in LPO levels (in the CCl4-induced hepatotoxicity model).
Significantly enhanced CAT, SOD, and TAS levels by 130%, 90.45%, and 61.39% respectively compared to the CCl4-treated group (in the CCl4-induced hepatotoxicity model).
Caused a 37.83% reduction in serum glucose level and a 25.37% increase in insulin level (in the Streptozotocin-induced hyperglycaemia model).
Reduced lipid peroxide levels by 51.77% and increased serum levels of CAT, SOD, and TAS by 93.02%, 70.79%, and 101.90%, respectively (in the Streptozotocin-induced hyperglycaemia model).

(+)-Piresil-4-O-beta-D-glucopyrasideSupplier

cjbscvictory Gold
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13348960310
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3003867561@qq.com
Chengdu RefMedic Biotech Co Ltd Gold
Tel
028-82253651 18140204969
Email
sales@refmedic.com
Chembest Research Laboratories Limited
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+86-21-20908456
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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