Hydrangel 8-O-glucoside Usage And Synthesis

Uses

Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC50: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction[1][2].

Definition

ChEBI: A member of the class of dihydroisocoumarins that is hydrangenol attached to a beta-D-glucopyranosyl residue at position 8 via a glycosidic linkage. It has been isolated from the roots of Scorzonera judaica.

References

[1] Matsuda H, et al. Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. Biol Pharm Bull. 1999 Aug;22(8):870-2. DOI:10.1248/bpb.22.870
[2] Hwang J, et al. Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches. Nutrients. 2021 Jan 17;13(1):254. DOI:10.3390/nu13010254

Hydrangel 8-O-glucoside(67600-94-6)Related Product Information

• Hydroxyecdysone
• alpha-Cyperone
• beta-Sitosterol
• (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one
• Artemether
• alpha-Terpineol
• MOSLOFLAVONE
• hydroxygenkwanin
• beta-Eudesmol
• 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one