Cyclobutanol, 3-amino-, hydrochloride (1:1), cis- Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder

color 

White

InChI

InChI=1/C4H9NO.ClH/c5-3-1-4(6)2-3;/h3-4,6H,1-2,5H2;1H/t3-,4+;

InChIKey

XUMSHCRPQCZRGX-HKTIBRIUNA-N

SMILES

N[C@@H]1C[C@H](O)C1.Cl |&1:1,3,r|

Safety Information

HS Code 

2922190090

Cyclobutanol, 3-amino-, hydrochloride (1:1), cis- Usage And Synthesis

Synthesis

General procedure for the synthesis of cis-3-aminocyclobutanol hydrochloride from tert-butyl (cis-3-hydroxycyclobutyl)carbamate: tert-butyl (1S,3S)-3-hydroxycyclobutylcarbamate (see Preparation 4A; 187 mg, 1 mmol, 1.0 equiv.) was dissolved in 4N HCl/MeOH solution (15 mL), and the reaction was stirred for 4 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated to afford (1S,3S)-3-aminocyclobutanol hydrochloride (120 mg, 0.98 mmol, 98% yield).ESI-MS (M+1): 88 (calculated value C4H9NO: 87).

References

[1] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 144

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