N-DeMethyl Ivabradine Hydrochloride
N-DeMethyl Ivabradine Hydrochloride Basic information
- Product Name:
- N-DeMethyl Ivabradine Hydrochloride
- Synonyms:
-
- N-DeMethyl Ivabradine Hydrochloride
- 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]aMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-3-benzazepin-2-one Hydrochloride
- S 18982
- N-DesMethyl Ivabradine Hydrochloride
- Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride)
- N-Desmethyl Ivabradine HCl
- Ivabradine Impurity b
- I-305
- CAS:
- 1246638-08-3
- MF:
- C26H35ClN2O5
- MW:
- 491.03
- Product Categories:
-
- Amines
- Chiral Reagents
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 1246638-08-3.mol
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N-DeMethyl Ivabradine Hydrochloride Chemical Properties
- Melting point:
- 193-196°C
- storage temp.
- Refrigerator
- solubility
- DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to off-white
- InChIKey
- MIIIKWNQFDQJGS-OZYVVJTJNA-N
- SMILES
- C([C@H]1CC2=CC(OC)=C(OC)C=C12)NCCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
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N-DeMethyl Ivabradine Hydrochloride Usage And Synthesis
Description
N-desmethyl Ivabradine is an active metabolite of ivabradine . Ivabradine is metabolized by the cytochrome P450 (CYP) isoform CYP3A4.
Chemical Properties
Beige Solid
Uses
Ivabradine (I940500) metabolite.
References
[1] GIAN MARCO ROSA. An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure.[J]. Expert Opinion on Drug Metabolism & Toxicology, 2014, 10 2: 279-291. DOI: 10.1517/17425255.2014.876005
N-DeMethyl Ivabradine HydrochlorideSupplier
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N-DeMethyl Ivabradine Hydrochloride(1246638-08-3)Related Product Information
- ent-Ivabradine Hydrochloride
- Ivabradine Impurity 1 Hydrochloride
- INDEX NAME NOT YET ASSIGNED
- 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide
- 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one
- 7-DeMethyl Ivabradine
- 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
- 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one)
- C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE
- (3,4-Dimethoxyphenyl)acetic acid
- Hydroxy Ivabradine
- N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
- 8-DeMethyl Ivabradine
- 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
- 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one)
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
- 4,5-Dimethoxy-1-cyanobenzocyclobutane