Methyl 3-chloro-4-fluorobenzoate Chemical Properties

Boiling point:

238℃

Density 

1.314

Flash point:

102℃

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid-Liquid Mixture

InChI

InChI=1S/C8H6ClFO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,1H3

InChIKey

RUTYNTBIMOCJMW-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC=C(F)C(Cl)=C1

Safety Information

HS Code 

2916310090

Methyl 3-chloro-4-fluorobenzoate Usage And Synthesis

Chemical Properties

off-white powder

Uses

Methyl 3-chloro-4-fluorobenzoate is a halogenated organic compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

Example 1 Preparation of methyl 3-chloro-4-fluorobenzoate In a 250 mL four-necked round-bottomed flask assembled with a mechanical stirrer, condenser tube and thermometer, 86.5 g of 3-chloro-4-fluorobenzoyl chloride was added. 28.1 g of anhydrous methanol was added slowly through a constant pressure dropping funnel. The reaction was exothermic and the temperature was raised to 60 °C spontaneously. The titration rate of methanol was controlled to maintain the reaction temperature at about 60 °C. The reaction mixture was stirred for 1 hour and the excess methanol was removed by distillation. A final 80 g of yellow oily material was obtained as methyl 3-chloro-4-fluorobenzoate in 97.29% yield.

References

[1] Patent: WO2003/95417, 2003, A1. Location in patent: Page/Page column 6

Methyl 3-chloro-4-fluorobenzoate(234082-35-0)Related Product Information

• METHYL 3-CHLORO-4-HYDROXYBENZOATE
• Methyl malonyl chloride
• 3-CHLORO-2,6-DIFLUOROBENZOIC ACID
• 3-CHLORO-4-FLUOROBENZENESULFONYL CHLORIDE
• 3-Chloro-2,4-difluorobenzoic acid
• 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
• 3-Chloro-1-(N,N-dimethyl)propylamine
• 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER
• Methyl 2-amino-4-bromobenzoate
• Methyl 3-bromo-5-iodobenzoate
• Methyl 4-fluoro-3-nitrobenzoate
• methyl 3-bromo-4-chlorobenzoate
• METHYL 2-BROMO-5-FLUOROBENZOATE
• 5-BROMO-2-NITRO-BENZOIC ACID METHYL ESTER
• Methyl 2-broMo-4-chlorobenzoate
• Methyl 5-bromo-2-chlorobenzoate
• 3-AMINO-5-BROMOBENZOATE