H2N-PEG8-tBu Chemical Properties

Boiling point:

544.3±45.0 °C(Predicted)

Density 

1.067±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Oil

pka

8.74±0.10(Predicted)

color 

Colorless to light yellow

InChI

InChI=1S/C23H47NO10/c1-23(2,3)34-22(25)4-6-26-8-10-28-12-14-30-16-18-32-20-21-33-19-17-31-15-13-29-11-9-27-7-5-24/h4-21,24H2,1-3H3

InChIKey

UMJVFHNJPJVDSB-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN

Safety Information

HS Code 

2942000090

H2N-PEG8-tBu Usage And Synthesis

Description

Amino-PEG8-t-butyl ester is a monodisperse PEG linker containing an amino group with a t-butyl protected carboxyl group.The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

H2N-PEG8-tBu is a cleavable 8-unit PEG-ADC linker for antibody drug conjugate (ADC) synthesis.

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