HO-PEG10-tBu
HO-PEG10-tBu Basic information
- Product Name:
- HO-PEG10-tBu
- Synonyms:
-
- HO-PEG10-CH2CH2COOtBu
- PEG11-t-butly ester
- HO-PEG10-tBu
- 33-Hydroxy-4,7,10,13,16,19,22,25,28,31-decaoxatritriacontanoic acid 1,1-dimethylethyl ester
- HO-PEG10-CH2CH2COOtBu
- Hydroxy-PEG10-t-butly ester
- Hydroxy-PEG10-t-butyl ester
- OH-PEG10-CH2CH2COOtBu
- CAS:
- 778596-26-2
- MF:
- C27H54O13
- MW:
- 586.71
- Product Categories:
-
- peg
- Mol File:
- 778596-26-2.mol
HO-PEG10-tBu Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DMF, DCM
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C27H54O13/c1-27(2,3)40-26(29)4-6-30-8-10-32-12-14-34-16-18-36-20-22-38-24-25-39-23-21-37-19-17-35-15-13-33-11-9-31-7-5-28/h28H,4-25H2,1-3H3
- InChIKey
- AEEGJXDZOJNBIY-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
HO-PEG10-tBu Usage And Synthesis
Description
Hydroxy-PEG10-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].
References
[1] Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent CN108707228A.
[2] Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5. DOI:10.1021/jm049705s
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