Basic information Safety Supplier Related

alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)

Basic information Safety Supplier Related

alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) Basic information

Product Name:
alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)
Synonyms:
  • alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)
  • Mal-PEG8-NHS
  • α-MaleiMidopropionyl-ω-succiniMidyl-8(ethylene glycol)
  • N-[27-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide
  • 31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester
  • Mal-NH-PEG8-NHS ester
  • Maleimide PEG8 succinimidyl ester
  • Maleimide-PEG8-NHS
CAS:
756525-93-6
MF:
C30H47N3O15
MW:
689.71
Product Categories:
  • peg
Mol File:
756525-93-6.mol
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alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) Chemical Properties

Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO : ≥ 100 mg/mL (144.99 mM)
pka
15.01±0.46(Predicted)
form 
powder
color 
Light yellowish
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Safety Information

WGK Germany 
3
HS Code 
2928009090
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alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) Usage And Synthesis

Description

Mal-amido-PEG8-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Heterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 39.2 angstroms.

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