Z-8-aMino-3,6-dioxaoctanoic acid Chemical Properties

Boiling point:

553.7±50.0 °C(Predicted)

Density 

1.093±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Viscous Liquid

pka

12.23±0.46(Predicted)

color 

Colorless to light yellow

Z-8-aMino-3,6-dioxaoctanoic acid Usage And Synthesis

Description

N-Boc-PEG8-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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