Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  DNA damage >  DNA / RNA Synthesis inhibitors >  CX-5461

CX-5461

Basic information Safety Supplier Related

CX-5461 Basic information

Product Name:
CX-5461
Synonyms:
  • CX-5461
  • 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-Methylpyrazin-2-yl)Methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxaMide
  • RNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem
  • CS-1938
  • 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
  • CX-5461/CX5461
  • 2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-N-[(5-Methyl-2-pyrazinyl)Methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]napht
  • 5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-
CAS:
1138549-36-6
MF:
C27H27N7O2S
MW:
513.61
Product Categories:
  • apis
  • Inhibitors
Mol File:
1138549-36-6.mol
More
Less

CX-5461 Chemical Properties

Boiling point:
739.9±60.0 °C(Predicted)
Density 
1.45
storage temp. 
+2C to +8C
form 
Light beige powder
pka
8.53±0.20(Predicted)
More
Less

CX-5461 Usage And Synthesis

General Description

A cell-permeable benzothiazole compound that selectively inhibits RNA polymerase I-mediated pre-rRNA transcription (IC50 = 142 nM in HCT-116), but not Pol II-mediated c-myc transcription, by preventing TAF SL1 and rDNA association). Effectively inhibits Pol I-dependent proliferation among 39 cancer cell lines (IC50<1 μM) in vitro and suppresses A375 (50 mg/kg/d p.o.) and MIA PaCa-2 (50 mg/kg/3d p.o.) tumor expansion in vivo.

Biochem/physiol Actions

Cell permeable: yes

CX-5461Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18516978288
Email
sales.gd@hwrkchemical.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Email
sale@labgogo.com