(R)-N-Boc-3-aminomethylpiperidine Chemical Properties

Boiling point:

299.4±13.0 °C(Predicted)

Density 

0.997g/mLat 25℃

refractive index 

n20/D 1.473

Flash point:

>110°C

storage temp. 

2-8°C

pka

10.12±0.29(Predicted)

form 

Liquid

color 

Clear colorless to pale yellow

CAS DataBase Reference

140645-23-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn,N

Risk Statements 

22-50-36/37/38

Safety Statements 

26-61

RIDADR 

UN 3082 9 / PGIII

WGK Germany 

3

HS Code 

2933399990

(R)-N-Boc-3-aminomethylpiperidine Usage And Synthesis

Uses

(R)-1-Boc-3-aminomethylpiperidine is an important intermediate in the synthesis of many drugs. A series of checkpoint kinase 1 (CHK1) inhibitors have been synthesized using (R)-1-Boc-3-aminomethylpiperidine as a starting material, showing some efficacy in treating rheumatoid arthritis. A series of drugs for treating diseases related to MCH (melanin-concentrating hormone) have also been synthesized using this compound, showing some effectiveness in treating metabolic disorders. G-protein-coupled receptor (GPCR) agonists containing the 1-N-Boc-4-methylaminomethylpiperidine structural unit have been synthesized, which can be used to treat obesity and diabetes. A series of drugs for regulating metabolism and treating cardiovascular diseases have also been synthesized using (R)-1-Boc-3-aminomethylpiperidine.

(R)-N-Boc-3-aminomethylpiperidine(140645-23-4)Related Product Information

• RESMETHRIN
• tert-Butyl methacrylate
• tert-Butyl acetate
• Butyl acetate
• Buprofezin
• Diethylene glycol monobutyl ether
• Diisobutyl phthalate
• tert-Butyl peroxyacetate
• 2-Amino-2-methyl-1-propanol
• Isobutyl chloroformate
• tert-Butanol
• tert-Butyl peroxybenzoate
• Hexamethyldisilazane
• Tris(trimethylsilyl)phosphate
• BUTYL OLEATE
• 2,2,6,6-Tetramethylpiperidinooxy
• Butyl acrylate
• 2,2,6,6-Tetramethyl-4-piperidinol