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Bisandrographolide C

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Bisandrographolide C Basic information

Product Name:
Bisandrographolide C
Synonyms:
  • Bisandrographolide C
  • 2(5H)-Furanone, 5-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]-1-(2,5-dihydro-2-oxo-3-furanyl)ethyl]-3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- (9CI)
CAS:
160498-02-2
MF:
C40H56O8
MW:
664.87
Mol File:
160498-02-2.mol
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Bisandrographolide C Chemical Properties

Boiling point:
832.6±65.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
pka
14.82±0.70(Predicted)
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Bisandrographolide C Usage And Synthesis

Uses

Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury[1].

References

[1] Gao S, et al. Unusual ent-Labdane Diterpenoid Dimers and their Selective Activation of TRPV Channels. J Org Chem. 2019 Nov 1;84(21):13595-13603. DOI:10.1021/acs.joc.9b01864

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