1-(3-Methoxypropyl)-4-piperidinamine Chemical Properties

Boiling point:

249℃

Density 

0.946

Flash point:

105℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

10.49±0.20(Predicted)

color 

Colourless to Pale Yellow

InChI

InChI=1S/C9H20N2O/c1-12-8-2-5-11-6-3-9(10)4-7-11/h9H,2-8,10H2,1H3

InChIKey

HIXAJGFVNMKLML-UHFFFAOYSA-N

SMILES

N1(CCCOC)CCC(N)CC1

1-(3-Methoxypropyl)-4-piperidinamine Usage And Synthesis

Uses

1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Synthesis

N-(1-(3-methoxypropyl)piperidin-4-yl)acetamide (10.72g, 0.05mol) was added to HCl-methanol solution (0.5M, 180ml), and the temperature was controlled at 2025°C After the reaction was detected, it was filtered, and the filter cake was washed with dichloromethane and dried to obtain 1-(3-Methoxypropyl)-4-piperidinamine with a yield of 96.4% and a purity of 99.7%.