4-c]pyridine Chemical Properties

Boiling point:

401.3±25.0 °C(Predicted)

Density 

2.219±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.98±0.40(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

HS Code 

2933399990

4-c]pyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-iodo-1H-pyrazolo[3,4-c]pyridine from 1H-pyrazolo[3,4-c]pyridine: 1H-pyrazolo[3,4-c]pyridine (300 mg, 2.52 mmol, 1.00 eq.), potassium hydroxide (KOH, 500 mg, 8.91 mmol, 3.50 eq.) and diiodomethane (1.28 g, 1.28 g, 2.00 eq.) were suspended in N,N-dimethylformamide (DMF, 10 mL). 5.04 mmol, 2.00 eq.) were suspended in N,N-dimethylformamide (DMF, 10 mL). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the reaction was quenched with water, the organic phase was extracted with ethyl acetate, the organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:1, v/v) to afford 3-iodo-1H-pyrazolo[3,4-c]pyridine (577 mg, 84% yield) as a yellow solid.LC-MS (ESI, m/z): 246 [M + H]+.

References

[1] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 357
[2] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00222
[3] Patent: WO2018/15818, 2018, A2. Location in patent: Paragraph 00177
[4] Patent: WO2012/93101, 2012, A1. Location in patent: Page/Page column 152
[5] Patent: WO2014/2053, 2014, A1. Location in patent: Page/Page column 51

4-c]pyridine(1082040-63-8)Related Product Information

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