Basic information Safety Supplier Related

(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride)

Basic information Safety Supplier Related

(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride) Basic information

Product Name:
(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride)
Synonyms:
  • (1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride)
  • methyl(1R,4S)-4-aminocyclopent-2-ene-1-carboxylatehydrochloride
  • Methyl (1R,4S)-4-amino-2-cyclopentene-1-carboxylate hydrochloride
  • Peramivir Impurity 13 HCl
  • (1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride
  • METHYL (1R,4S)-4-AMINOCYCLOPENT-2-ENE-1-CARBOXYLATE HCL
  • (1R,4S)-(-)-METHYL-4-AMINOCYCLOPENT-2-EN-1-CARBOXYLATE HYDROCHLORIDE
  • Peramivir Impurity 56 HCl
CAS:
426226-35-9
MF:
C7H12ClNO2
MW:
177.62868
Mol File:
426226-35-9.mol
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(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride) Usage And Synthesis

Uses

(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride)Supplier

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