Basic information Safety Supplier Related

VU0238441

Basic information Safety Supplier Related

VU0238441 Basic information

Product Name:
VU0238441
Synonyms:
  • VU0238441
  • 1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoroMethyl)phenyl]Methyl]-
  • 7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione
  • 7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione
  • 7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione
  • mAChR,Inhibitor,VU-0238441,VU0238441,Muscarinic acetylcholine receptor,VU 0238441,inhibit
CAS:
85511-68-8
MF:
C16H9ClF3NO2
MW:
339.7
Mol File:
85511-68-8.mol
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VU0238441 Chemical Properties

Boiling point:
441.7±55.0 °C(Predicted)
Density 
1.500±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 125 mg/mL (367.97 mM)
pka
-3?+-.0.20(Predicted)
form 
Solid
color 
Brown to red
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VU0238441 Usage And Synthesis

Biological Activity

VU0238441 is a positive allosteric modulator (PAM) of pan-muscarinic acetylcholine receptor (mAChR) with EC50 values of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > for M5, M3, M2, M1 and M4, respectively 10 μM.

in vitro

VU0238441 is an analogue of VU0119498.

target

< td class="border-bottom: 1px dotted #ccc;padding: 5px;"> 2.1 μM
TargetValue
mAChR M5
(Cell-free assay)
mAChR M3
(Cell-free assay)		 2.2 μM
mAChR M2
(Cell-free assay)		 2.8 μM
mAChR M1
(Cell-free assay)		 3.2 μM
mAChR M4
(Cell-free assay)		 >10 μM

VU0238441Supplier

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Email
lucy@atkchemical.com
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Email
sales@twochem.com
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VU0238441(85511-68-8)Related Product Information