3-Ethoxy-4-methoxy benzonitrile Chemical Properties

Melting point:

70℃

Boiling point:

281.9±25.0℃ (760 Torr)

Density 

1.09±0.1 g/cm3 (20 ºC 760 Torr)

Flash point:

109.2±16.4℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow

InChIKey

XTIINWPNAMHVDG-UHFFFAOYSA-N

Safety Information

RIDADR 

3439

HazardClass 

6.1

PackingGroup 

III

HS Code 

2926907090

3-Ethoxy-4-methoxy benzonitrile Usage And Synthesis

Chemical Properties

White to Light yellow powder to crystal

Uses

3-Ethoxy-4-methoxy benzonitrile can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

In a 100 ml flask in the, adding 3-hydroxy-4-methoxy phenyl nitrile 10g (67.11mmol), bromoethane 25 ml (335.2mmol), potassium carbonate 10.25g, dimethyl formamide 50 ml, heating and stirring to 100 ??C. TLC monitoring reaction, reaction 8h, stop heating. Natural cooling to room temperature, water 100 ml, the ethyl acetate extraction, the organic phase is dried with anhydrous sodium sulfate, ethyl acetate solvent turns on lathe does the white solid obtained 11.09g.

3-Ethoxy-4-methoxy benzonitrile(60758-86-3)Related Product Information

• 3-Nitrophthalic acid
• Apremilast Impurity 19
• Apremilast Impurity 15
• Apremilast impurity 18
• 1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-
• 4-acetamidophthalic acid
• 1-Methyl-3-nitrophthalate
• 4-Nitrophthalic acid
• Apremilast Impurity 4
• BenzeneMethanaMine, 4-ethoxy-3-Methoxy-a-[(Methylsulfonyl)Methyl]-
• Apremilast-d8
• Apremilast Impurity 25
• 1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
• Apremilast Impurity 28
• (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
• Apremilast Impurity 34
• (R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine
• 3-ETHOXY-4-METHOXYBENZOIC ACID