5-broMo-1-MethylpyriMidin-2-one Chemical Properties

Boiling point:

215.9±50.0 °C(Predicted)

Density 

1.73±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

0.31±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2933599590

5-broMo-1-MethylpyriMidin-2-one Usage And Synthesis

Synthesis

Step 1: Synthesis of 5-bromo-1-methylpyrimidin-2(1H)-one A mixture of 5-bromopyrimidin-2(1H)-one (3 g), iodomethane (1.1 mL) and potassium carbonate (2.4 g) in N,N-dimethylformamide (60 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The residue was partitioned between water and dichloromethane. The organic phase was washed with brine, dried over anhydrous magnesium sulfate, and then concentrated to afford the target product 5-bromo-1-methylpyrimidin-2(1H)-one. Yield: 385 mg; liquid chromatography (Method 9): retention time t R = 0.25 min; mass spectrometry (ESI+): m/z = 189 [M + H]+.

References

[1] Patent: US2013/252937, 2013, A1. Location in patent: Paragraph 0767
[2] Patent: WO2013/144097, 2013, A1. Location in patent: Page/Page column 164
[3] Patent: WO2015/160636, 2015, A1. Location in patent: Page/Page column 155
[4] Patent: WO2015/160634, 2015, A1. Location in patent: Page/Page column 142

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