1-Chloro-2,5-difluorobenzene Chemical Properties

Melting point:

24.6 °C

Boiling point:

126-128 °C(lit.)

Density 

1.352 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.478(lit.)

Flash point:

68 °F

storage temp. 

2-8°C

form 

liquid

color 

Clear, faint yellow

BRN 

2081082

CAS DataBase Reference

2367-91-1(CAS DataBase Reference)

NIST Chemistry Reference

1-Chloro-2,5-difluorobenzene(2367-91-1)

Safety Information

Hazard Codes 

Xn,F,Xi

Risk Statements 

10-20/21/22-36/37-36/37/38-11

Safety Statements 

16-26-36-37/39

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

Hazard Note 

Flammable

HazardClass 

3

PackingGroup 

III

HS Code 

2903998090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Chloro-2,5-difluorobenzene Usage And Synthesis

Chemical Properties

Colorless liquid

Synthesis

GENERAL STEPS: In a FEP or PFA reactor fitted with a PTFE-lined magnetic stirring bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 ml per ml of C6H5R), and BF3-Et2O (1.3-1.5 mmol per mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol per mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and cooled to 0-5 °C again. After the addition was completed, the dark colored solution was continued to be stirred at 22-25°C for 15-30 minutes. At the end of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm). The organic layer was dried with magnesium sulfate and analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (GC/MS data).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

1-Chloro-2,5-difluorobenzene(2367-91-1)Related Product Information

• 1,3-Difluorobenzene
• 1,3-Dichlorobenzene
• Transfluthrin
• 2,4-Dichlorobenzyl chloride
• Permethrin
• Florfenicol
• Flumethrin
• 4-Fluorobenzaldehyde
• 1,2-Difluorobenzene
• 1,2-Dichlorobenzene
• Difluorochloromethane
• 4-CHLORO-2,5-DIFLUOROBENZOIC ACID
• Chloropentafluorobenzene
• 1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE
• FENFLURAMINE
• p-Dichlorobenzene
• 2-CHLORO-3,6-DIFLUOROBENZOIC ACID
• 1,3-DICHLOROTETRAFLUOROBENZENE